Radioimmunoassay of Human Plasma Thyrotropin*
نویسندگان
چکیده
منابع مشابه
Radioimmunoassay of Human Plasma Thyrotropin.
Many pituitary hormones possess partial or complete immunological species specificity. Earlier reports suggested that thyrotropin (TSH) did not have such specificity since the biological activity of human pituitary or plasma TSH could be neutralized by antisera to bovine TSH in doses similar to that which blocked the biological activity of bovine TSH (2, 3). However, recent studies have shown t...
متن کاملInterference in a radioimmunoassay for human thyrotropin.
Abnormally high plasma thyrotropin values were found by radioimmunoassay in some patients when an antiserum to porcine thyrotropin was used, normal results being obtained with an antiserum raised to human thyrotropin. These discrepancies were found in some subjects with no biochemical or clinical evidence of hypothyroidism and occasionally in sera from patients with unequivocal hyperthyroidism....
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The importance of early diagnois and treatment of congenital hypothyroidism has been well established, and several screening programs have been undertaken to detect neonates with this disorder by measurement of concentrations of thyrotropin or thyroxine in the serum. However, measurement of either hormone alone may fail to identify all affected patients. Accordingly, we have established a simul...
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A radioimmunoassay procedure for determination of somatostatin immunoactivity in human plasma is described. Labelling of tyrosine-1-somatostatin is performed by chloramine T. Specific activity of the tracer is 1.34 mol iodine for 1 mol of somatostatin. The immunoreactivity is 85%. Antisera are produced in rabbits at a titre of 179 X 10(-12) mol somatostatin per ml antiserum. Human plasma is ext...
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A sensitive, specific radioimmunoassay of calcitonin is described, suitable for measuring the hormone in peripheral plasma of normal man. With this assay we have demonstrated that calcitonin is detectable under basal Conditions and the concentrations respond to induced, and spontaneous hypercalcemia and induced hypocalcemia. The mean value for basal calcitonin of normal men was 182 pg/mI (range...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1965
ISSN: 0021-9738
DOI: 10.1172/jci105234